Gurren Lagann is one of my favorites, and the ending always tears me to shreds. Also the space portions during the big battles against the Anti-spirals (should be fairly obvious why). Strangely, the mid-season-1 drop (just before Nia was introduced) never got to me.
Grave of the Fireflies is kind of the wrecking-ball version of this. Powerful, not subtle, and leaves you utterly devastated.
(Runner-up for me might be Gurren Lagann.)
Gurren Lagann is one of my favorites, and the ending always tears me to shreds. Also the space portions during the big battles against the Anti-spirals (should be fairly obvious why). Strangely, the mid-season-1 drop (just before Nia was introduced) never got to me.