MintPress News supported former Syrian president Bashar al-Assad, and supports the governments of Russia and Iran.[10][11] It opposes the governments of Israel and Saudi Arabia,[12] and reports geopolitical events from an anti-Western perspective.[13] In one contentious article, MintPress News wrote that the Ghouta chemical attack in Syria was perpetrated by rebel groups rather than by the Syrian government, a claim pushed by the Russian and Syrian governments and rejected by much of the international community.[11]

MintPress News was a major media domain that spread disinformation about the White Helmets, a Syrian volunteer organization.[14] The site has been accused of regularly publishing pro-Russian propaganda,[15] and has been described as a conspiratorial website by media studies and disinformation scholars.