But on the other hand, it also means the death of copyright

What kind of chaos is this. This is madness

Where they both complain about being single and why can’t they find someone like them

Please no, don’t make the techno fascist surveillance dystopia worse

The reporting of BRCA2 is driving me nuts. Everyone has the BRCA2 gene. The risk comes from pathogenic variations to the gene. BRCA2 is a good gene to screen on for family history for certain types of cancers, because germline variants are more common than somatic variants.

I think this reporter misunderstood that the gene always exists in every person and thought BRCA2 was a type of variation

I bet they’d get along with my neighbors. I live across from a cemetery

Capitalists

Reminds me of a tool at my job called Picard. No idea what it does, but my disappointment was palpable when I found out that there wasn’t even a hint of a star trek easter egg

Good question! Some people will probably cite the electromagnetic spectrum, but in this case the scientific principle is much simpler. It’s called “because I felt like it”

My weird lil guy was a monk multiclassed with wizard, because he was obsessed with going fast. He also loved taking drugs. There may have been a couple sonic comparisons

When I was unemployed, I would take a nap whenever I wanted and then sleep for as long as I felt like. I miss that sometimes

god, this code is awful. Who wrote this?

git blame

Oh

Definitely using this reaction meme

I’m not familiar with the name of the file I’m currently working with tbh. It’s used to create the annotation files for regenie analyses. It has every variant for every gene within the biobank. There’s far more than just missense; there are stop/start gain/loss, splice donor/acceptor, frameshifts, and ptv. It contains primateAI scores, spliceAI scores, cava data, clinvar data, and more.

yes, all that data is extrapolated directly from DNA. It’s a huge amount of information. All the DNA in a single human cell is directly translated to about 750MiB. Now, add in the fact that genomic studies use biobanks, like the UK Biobank, which contains the genetic info of hundreds of thousands of people. The data we can extrapolate from DNA is absolutely massive.

Well it varies depending on what the file is meant for. Usually there’s columns like chromosome, variant position, reference nucleotide, observed nucleotide, type of variation, codon sequence, gene name, etc.

There’s also columns that result from various analyses. In the file I’ve been working on lately, there are columns such as variant impact, level of confidence, pathogenicity, clinical significance, etc.

No, none of those guys are involved afaik. The one that made the first breakthrough in artificial life is ran by the same dude who competed with the Human Genome Project to map 99% of the human genome. They modified an extremely simple bacteria that only had something like 300 base pairs

I’m a data analyst at a medical nonprofit, primarily doing analyses on germline variants for rare forms of cancer. I’m new to this kind of work, but had a decent educational background in biology.

Something I’ve learned is that genetics are complicated as hell. A single gene can produce multiple different proteins, and proteins change over time due to somatic variation. Only 1% of the genome are protein coding, called exomes. Exomes can be affected by variations to start and stop codons, non coding regions, and untranslated regions. There are entire fields dedicated to studying genome-wide, exomics, transcriptomics, proteomics, phenomics, and probably several others that I don’t know about. The amount of data involved with these fields is in the tebibytes region. Have you ever seen a “small” 3GiB csv? I have. The filtered and cleaned data frames created by genetics are over 100 columns wide and have nearly 5 million entries.

There are companies creating artificial life by generating custom chromosomes. There’s a whole field of computer science dedicated to biological computing, using DNA as a storage medium. There are companies dedicated to simply classifying genes.

DNA is cool as hell.

I just checked Microsoft’s website. They’re trying to make windows enterprise a subscription model. The current cost for what they’re calling “windows 365” is $99/yr per user. They’re saving nearly $250 million a year, or €211 Million

Why the hell don’t they just create an apt repository?